| Density | 0.932[at 20℃] |
| Water Solubility | 19.68g/L at 90℃ |
| Solubility | Insoluble in water, soluble in alcohol and pyridine. |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | The appearance is brownish yellow to white fine powder, with a slightly bitter taste. |
| HS Code | 1302190200 |
damp-heat jaundice, heatstroke diarrhea, sand drenching, blood drenching, carbuncle swelling, sore poison, fall and flutter injury. Centella asiaticosa can tighten the epidermis and dermis connecting part, can make the skin soft, help to solve the skin relaxation phenomenon (especially postpartum mother), make the skin smooth and elastic; Help promote the formation of collagen in the dermis, regenerate fibrin, reconnect it, fundamentally eliminate the mother's lines, and make the skin compact and smooth. It also helps to heal damaged tissues and tighten the skin. It can not only promote the close connection between epidermis and dermis, but also inhibit the increase of fat cells, prevent skin edema and obesity. Dicotyledonous Umbelliferae, detumescence detoxification to remove abscess. Centella Asiais can tighten the epidermis and dermis connecting part, can make the skin soft, help promote the formation of collagen in the dermis, have the effect of making the skin firm.
Centella asiatica extract contains a variety of triterpenoids, including α-balm resinol structure. The main components are asiaticoside and hydroxyasiaticoside, with a brownish yellow to white fine powder and a bitter taste. For the treatment of damp-heat jaundice, heat stroke diarrhea, sand drenching blood, carbuncle swollen sore poison, fall flutter injury have excellent results.
Place in a cool, dry place away from light and high temperature.
| Plant Source: | Centella asiatica |
| LogP | -0.333 |
| plant extract | Centella asiatica has a medicinal history of more than 2000 years in China, many other countries and regions such as Madagascar, South Africa, india, Southeast Asian countries and South America also use Centella asiatica as a brain tonic, diuretic, and an adjunct to leprosy, ulcers, and dermatological drugs. Centella asiatica is included in the Pharmacopoeia of China, France, Spain, Mexico, India, the Netherlands, Venezuela and other countries. The Centella asiatica extract is the whole grass of centtella asiatica (L.) Urb., a plant of the umbelliferae family. Commercial extracts are usually labeled as Centella asiatica-containing acids by 9%. Note: Centella asiatica standard Extract specification: Asiatic acid 29% ~ 30%, asiaticoside 40%, hydroxy Asiatic acid 29% ~ 30%, madecassoside 1%~ 2%. |
| Centella asiatica | . Mainly produced in Jiangsu, Zhejiang, Jiangxi, Fujian, Guangdong, Guangxi, Yunnan, Sichuan and other places. Harvest in summer and autumn, remove sand, dry or fresh use. There are more than 20 species in the world, mainly distributed in the tropical and subtropical regions of the northern and southern hemisphere, mainly in South Africa, India, Sri Lanka, Malaysia, Indonesia, Australia, and Japan. China produces only one kind of Centella asiatica, mainly distributed in the south of the Yangtze River basin, born in the road side, the ditch, the wet field, often grow into pieces. [Traits] Centella asiatica is often rolled into a mass. The root was cylindrical, 2 ~ 4cm in length, 1~1.5 in diameter, and the surface was light yellow or gray yellow. Stems slender, curved, yellow-brown, with fine longitudinal wrinkles, often with whiskers on nodes. The leaves were more contracted and broken, and the intact ones were flat and then showed nearly round or kidney-shaped, 1 ~ 4cm in diameter, gray-green, with thick and blunt teeth on the margin; The petiole was 3 ~ 6cm in length, twisted. UMBEL, axillary, short. Double suspensions of fruit, oblate, with obvious protuberance of the longitudinal ribs and fine net lines, fruit stem is very short. The taste was mild. Function indications: clearing heat and removing dampness, detoxification and detumescence. It is used for damp-heat jaundice, heat stroke Diarrhea, sand drenching blood, furunculosis, sore and poison, fall and fall injury. Figure 1 is a picture of Centella asiatica plants |
| components | Centella asiatica mainly contains triterpenoid acids and triterpenoid saponins. The triterpene acids are Asiatic acid, hydroxy Asiatic acid, isohydroxy Asiatic acid, and malagama Asiatic acid. And betulinic acid, etc. Triterpenoid saponins include Asiaticoside, Madecassoside, Brahmoside, Brahminoside, isosoniside (Isothankuniside) and so on. Minpei K et al. isolated five new triterpene glycosides from Centella asiatica. Polyene alkyne hydrocarbons: Centella asiatica underground part contains a variety of polyalkyne alkene compounds, at least 16 kinds of separation. It also contains Vellarin, fruit acid, Vc, Centellose, asiaticoside, flavonols, fatty acids, and trace elements needed by the human body such as calcium, iron, potassium, magnesium, manganese, rubidium, selenium, zinc, etc. Fig.2 chemical structural formula of asiaticoside and Asiatic acid |
| extraction method | 1. Experiment on extraction and separation of Centella asiatica total glycosides Centella asiatica (whole herb) was extracted with 75% ethanol, the extract was passed through the liquid and concentrated under reduced pressure to no alcoholic taste, and chlorophyll was removed by extraction with a little petroleum ether, and the concentrated solution was passed through macroporous resin, first wash with a small amount of water, then elute with 50% ethanol, concentrate the eluate, vacuum dry, dissolve the dried product with a little distilled water, adjust the pH to 3 to 4 with concentrated hydrochloric acid, precipitate some weak acidic substances, chloroform was added for extraction to remove fat-soluble impurities, concentrated ammonia was added to adjust pH to 6 to 7, and then extracted with n-butanol saturated with water for three times. The extract was recovered to near dryness under reduced pressure, and then dissolved a little by adding 95% alcohol, the refined product can be obtained by low-temperature vacuum drying. With the determination of residual iodometric content in more than 93%. 2. Centella asiatica extract (9%) production process the medicinal materials were crushed into coarse powder, extracted with 70% alcohol reflux, the extract was separated, the extract was decompressed and the ethanol was recovered to the end, and the concentrated solution was centrifuged, the Centrifugal liquid was concentrated under reduced pressure to 12~15 wave (heat test), and spray dried to obtain the finished product of Centella asiatica extract. The total triterpenoid compounds in the extract of Centella asiatica produced by this process were 9%~ 10%, and the yield was about 20%. |
| pharmacological action | 1. Anti-gastric ulcer effect Centella asiatica extract can increase the level of gamma-aminobutyric acid (GABA) in the brain of gastric ulcer model rats, and can also reduce gastric acid secretion and pepsin activity, showing a good anti-ulcer effect. 2. Memory enhancing effect the water extract of Centella asiatica can significantly improve the memory of rats in passive avoidance reaction test. 3. The role of the central nervous Centella asiatica extract has a strong central inhibitory effect and cholinergic effect. 4. Antibacterial effect Centella asiatica water extract has antibacterial and antiviral effect, and has inhibitory effect on Pseudomonas aeruginosa, Proteus and Staphylococcus aureus. In addition, asiaticoside can also dissolve the wax membrane of bacteria. 5. Stimulate the biosynthesis of Centella asiatica total triterpenoid extract can significantly affect cell proliferation and protein and proteoglycan biosynthesis, collagen and fibronectin increased significantly. 6. The role of skin tissue can accelerate wound healing, promote skin growth, local leukocytosis, connective tissue vascular network hyperplasia, increased mucus secretion. 7. Other effects the crude extract of Centella asiatica was orally administered to female rats, showing obvious and lasting activity of reducing fertility; Reducing systolic blood pressure and heart rate; Anti-virus, anti-Nervousness, anti-stress effect. |
| clinical efficacy | Centella asiatica extract can be used to treat gastric ulcer, hypertension, skin diseases such as intractable trauma, skin tuberculosis, leprosy, etc. Clinical mainly for the treatment of chronic bronchitis, flow cell carrier, hepatitis B, mumps, acute jaundice hepatitis, digestive tract mold, a variety of Fever, poisoning and nephritis, uremia and other diseases. India and other countries use it for brain, diuresis, leprosy, skin diseases, and as an adjunctive treatment for obesity. |
| toxic and side effects | individuals with sensitive contact dermatitis may have systemic pruritus after oral administration, which can be avoided by intramuscular injection; Photosensitivity reaction may occur. Repeated administration of asiaticoside may be related to skin carcinogens. Centella asiatica extract in rats by intraperitoneal injection of the median lethal dose of 1.39g/kg; Asiaticoside in mice, rabbits subcutaneous injection of 0.04~0.05g/kg can produce symptoms of poisoning, 0.2~0.25g/kg can increase the bleeding time, leading to bleeding; Oral administration of 1 g/kg to mice and rabbits can tolerate. |
| purpose | is a regulator for wound healing, which can activate epithelial cells and promote the formation of normal granulation tissue, can inhibit the proliferation of fibroblasts |